Impaired autophagy contributes to the aggravated deterioration of osteoarthritis articular cartilage by peroxisome proliferator-activated receptor α deficiency, associated with decreased ERK and Akt activation

Abstract Background Although the chondroprotection of peroxisome proliferator-activated receptor ? (PPAR?) activation against osteoarthritis (OA) has been revealed, the regulatory mechanism of PPAR? deficiency to aggravate osteoarthritic cartilage deterioration remains unclear.Here, we aimed to investigate whether and how autophagy is involved in O

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Taxa of the Nasal Microbiome Are Associated with Influenza-Specific IgA Response to Live Attenuated Influenza Vaccine.

Live attenuated influenza vaccine (LAIV) has demonstrated varying levels of efficacy against seasonal influenza; however, LAIV may be used as a tool to measure interactions between the human microbiome and a live, replicating virus.To increase our knowledge of this interaction, we measured Gloves changes to the nasal microbiome in subjects who rece

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Make to learn: invention through emulation

Abstract The Make to Learn coalition was established to identify effective pedagogical approaches for employing makerspaces for educational innovation in schools.The Make to Learn coalition is anchored by the Make to Learn Laboratory in the Curry School of Education at the University of Virginia and the Laboratory School for Advanced Manufacturing

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